Since 1995 Catharine Clark Gallery has been situated in the Union Square area of downtown San Francisco, California. The gallery program, which began in 1991 as Morphos Gallery, presents the work of local, national and international emerging and mid-career contemporary artists. A wide range of media is included in the gallery stores with an emphasis on content driven work that challenges both the traditional use of materials and formal aesthetics.

Catharine Clark has pioneered the presentation of new media art in San Francisco and, to date, has the only commercial gallery in the area with a dedicated video project room. Exhibitions are hosted on a 4 – 6 week schedule and generally feature one or two solo artist exhibitions, in addition to video and project room installations. Featured artists in the video room have included such established figures as William Kentridge, Kutlug Ataman and Ann Hamilton.