Marc Selwyn Fine Art has a diverse program which includes established artists as well as mid-career talent. The gallery takes an international perspective and has exhibited artists from the United States, Cuba, and several European countries. Many of the gallery's more established artists are characterized by a minimal/conceptual aestheic, while exhibitions of younger artists have been more varied and experimental.
Artists represented/exhibited by the gallery include Mel Bochner, Bernd and Hilla Becher, James Casebere, Douglas Huebler (a portion of the Estate), Tom Knechtel, Robert Mapplethorpe, Roy McMakin, Richard Misrach, the estate of Lee Mullican, Roman Opalka, Robert Overby, Paul P., and Tony Smith.
The gallery became independent of its former partnership with Anthony Grant in New York and inaugurated its new space in Los Angeles near the Los Angeles County Museum of Art with an exhibition of Robert Mapplethorpe photographs curated by Catherine Opie.